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Indeed, basic research provides the broad base of knowledge that pro-vides the foundation for the development of practical solutions to recognized problemsand needs. Epithelial cells in numerouslocations, particularly sweat glands, mammary glands, salivaryglands, and the iris of the eye, may acquire the characteristicsof smooth muscle cells (myoepithelial cells). Both of these interactions (TCR or anti-class IIantibodies and LAG-3) with the MHC-class II proteins of the tumor directly impact the anti-tumor T cell response.
This will be the topic discussed in Chapter 4, but next inorder fully understand how Tregs can be manipulated, their functional capabilities (ability toinhibit T cell responses) must be examined. (1991) Periodiclimb movements in sleep in community dwelling elderly. Part of this trend towards general management has involved what Offe (1984)has referred to as the ‘commodification’ of welfare services.